Redox Imbalance in Migraine: From Preclinical Biomarker Discovery to Clinical Application for Metabolic Therapies
Abstract
This project seeks to identify prognostic biomarkers, such as HIF-1α and its correlation with the CGRP, to distinguish subsets of migraine patients with redox imbalances. These biomarkers, along with other indicators of oxidative and reductive stress, will be quantified through studies involving both animal models and human subjects. Furthermore, our research will employ various therapeutic approaches targeting mitochondrial redox balance. By identifying patients with specific redox imbalances, we aim to tailor treatments that target mitochondrial redox balance, offering a personalised therapeutic strategy for a subset of migraine sufferers.
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