Support for ERC grant application EpiNeuroLife: Epigenome in the Life of a Neuron
Abstract
How do neurons maintain their function throughout life? Neurons are born early in development and are not regenerated during an individual’s lifetime. Therefore, after maturation, our neurons must remain functional throughout life, which in humans can be up to a hundred years of more. The goal of my ERC Starting Grant 2024 proposal EpiNeuroLife was to uncover how the formation of the epigenetic landscape during neuronal maturation contributes to the maintenance of neuronal gene expression and function during adulthood and ageing. My preliminary studies show that developing neurons in the mouse cerebellum accumulate extremely high levels of the repressive histone modification H3K27me3 during maturation, which I hypothesise is critical for regulating chromatin compaction and neuronal gene expression later in life. In MOB3ERC113, I will generate supporting data for my ERC application to uncover the mechanisms of H3K27me3 deposition in neurons.
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